To the extent that federalism still exists - and it's a reach to say it still does - social media is rapidly poaching what survives of it. Indiana recently passed the Religious Freedom Restoration Act, Alabama recently passed its Freedom of Religion in Marriage Protection Act, and the national social media apparatus put so much pressure on those governments the laws were quickly defanged by the online maelstrom.
This phenomenon is only going to grow more powerful.
For all the talk of dysfunction in politics and the country being more divided than ever, there is an airtight consensus on the social issues among the nation's power brokers. This has been proven time and again since sites like Twitter and Gawker grew from novelties to sniper rifles. Doesn't matter how traditional Indiana might want to be. Its officials and businesses cannot withstand the instantaneous human wave attacks.
So with federalism fully dead and the national consensus flattening any differences from state to state, the importance of having a VP from a swing state is null and void. No matter how popular he is at home, if he dissents the coast-to-coast digital derision will soon make him a goat at home. You can select Marco Rubio as VP thinking you'll get Florida, but his stances on abortion and the Indiana law would swirl around his head like radioactive gnats. Every little gaffe on the campaign trail would be traced back to those stances and votes, probably on a daily basis. The national media/social media scrutiny (with power broker reinforcement) would prevent him from carrying Florida for whomever the presidential candidate was. A Jeb/Rubio ticket might carry Florida, but otherwise no chance.
Ryan didn't carry Wisconsin for Romney, Walker wouldn't do any better, Portman wouldn't deliver Ohio for anyone (voted against partial birth abortion for starters), Santorum wouldn't deliver Pennsylvania. The list goes on. The intersection of the power broker consensus with the cost free bully pulpit of social media makes it impossible to step outside whatever this afternoon's standard is for acceptable debate (don't get comfortable, it will change by dinner time).
Having someone like Perry or Cruz as VP (not that it would happen) isn't necessary to help carry Texas because Texas is still a sort of American Switzerland; remaining relevant even as it stands somewhat outside the consensus. This won't last forever of course.
The power broker consensus is making it less and less possible to "vote with your feet." Any openings for state-level legislative arbitrage are pretty much gone. In three or four years you won't even need the caveat of "pretty much."
The old adage was that all politics is local. Social media (and political correctness) means now all politics is national.